Ginsberg Yuval, Khatib Nizar, Weiner Zeev, Beloosesky Ron
Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel.
The Ruth & Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Rambam Maimonides Med J. 2017 Apr 28;8(2):e0028. doi: 10.5041/RMMJ.10305.
A growing body of evidence implies that maternal inflammation during pregnancy is associated with increased risk of neurodevelopmental disorders in the offspring. The pathophysiological mechanisms by which maternal inflammation evokes fetal brain injury and contributes to long-term adverse neurological outcomes are not completely understood. In this review, we summarize 10 years of our research experience on maternal inflammation and the implications upon the fetal/offspring brain. We review our findings regarding the underlying mechanisms that connects maternal inflammation and fetal brain injuries (e.g. cytokines, oxidative stress); we discuss our imaging, pathological and behavioral test results which support brain damage following maternal inflammation; and finally we describe some of the therapeutic strategies which might prevent the damage.
越来越多的证据表明，孕期母体炎症与后代神经发育障碍风险增加有关。母体炎症引发胎儿脑损伤并导致长期不良神经后果的病理生理机制尚未完全明确。在本综述中，我们总结了10年来关于母体炎症及其对胎儿/后代大脑影响的研究经验。我们回顾了关于连接母体炎症和胎儿脑损伤的潜在机制（如细胞因子、氧化应激）的研究结果；讨论了支持母体炎症后脑损伤的影像学、病理学和行为测试结果；最后描述了一些可能预防损伤的治疗策略。
