探索褪黑素在女性生殖健康中的多方面作用：从卵泡发育到泌乳及其在产科综合征中的治疗潜力。
Exploring melatonin's multifaceted role in female reproductive health: From follicular development to lactation and its therapeutic potential in obstetric syndromes.
作者信息
Li Qihui, Zheng Tenghui, Chen Jiaming, Li Baofeng, Zhang Qianzi, Yang Siwang, Shao Jiayuan, Guan Wutai, Zhang Shihai
机构信息
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China.
Guangdong Province Key Laboratory of Animal Nutrition Control, College of Animal Science, South China Agricultural University, Guangzhou 510642, China; College of Animal Science and National Engineering Research Center for Breeding Swine Industry, South China Agricultural University, Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture, South China Agricultural University, Guangzhou, China.
出版信息
J Adv Res. 2025 Apr;70:223-242. doi: 10.1016/j.jare.2024.04.025. Epub 2024 Apr 30.
BACKGROUND
Melatonin is mainly secreted by the pineal gland during darkness and regulates biological rhythms through its receptors in the suprachiasmatic nucleus of the hypothalamus. In addition, it also plays a role in the reproductive system by affecting the function of the hypothalamic-pituitary-gonadal axis, and by acting as a free radical scavenger thus contributing to the maintenance of the optimal physiological state of the gonads. Besides, melatonin can freely cross the placenta to influence fetal development. However, there is still a lack of overall understanding of the role of melatonin in the reproductive cycle of female mammals.
AIM OF REVIEW
Here we focus the role of melatonin in female reproduction from follicular development to delivery as well as the relationship between melatonin and lactation. We further summarize the potential role of melatonin in the treatment of preeclampsia, polycystic ovary syndrome, endometriosis, and ovarian aging.
KEY SCIENTIFIC CONCEPTS OF REVIEW
Understanding the physiological role of melatonin in female reproductive processes will contribute to the advancement of human fertility and reproductive medicine research.
背景
褪黑素主要在黑暗期间由松果体分泌，并通过其在下丘脑视交叉上核中的受体调节生物节律。此外，它还通过影响下丘脑 - 垂体 - 性腺轴的功能以及作为自由基清除剂，从而有助于维持性腺的最佳生理状态，在生殖系统中发挥作用。此外，褪黑素可以自由穿过胎盘以影响胎儿发育。然而，目前对褪黑素在雌性哺乳动物生殖周期中的作用仍缺乏全面了解。
综述目的
在此，我们聚焦于褪黑素在雌性生殖从卵泡发育到分娩过程中的作用以及褪黑素与泌乳之间的关系。我们进一步总结了褪黑素在治疗先兆子痫、多囊卵巢综合征、子宫内膜异位症和卵巢衰老方面的潜在作用。
综述的关键科学概念
了解褪黑素在雌性生殖过程中的生理作用将有助于人类生育和生殖医学研究的进展。
Zotero 插件