干细胞微环境中的代谢协同作用。
Metabolic Teamwork in the Stem Cell Niche.
作者信息
Roper Jatin, Yilmaz Ömer H
机构信息
David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Division of Gastroenterology, Tufts Medical Center, Boston, MA 02111, USA; Molecular Oncology Research Institute, Tufts Medical Center, Boston, MA 02111, USA.
David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA.
出版信息
Cell Metab. 2017 May 2;25(5):993-994. doi: 10.1016/j.cmet.2017.04.019.
Abstract
Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth cells provides lactate to drive mitochondrial oxidative phosphorylation in intestinal stem cells.
摘要
邻近细胞能够支持干细胞分化，但干细胞微环境中的代谢活动尚不清楚。最近的一项研究（Rodríguez-Colman等人，2017年）揭示了肠道干细胞微环境中的一种代谢协作关系：微环境中的潘氏细胞进行糖酵解，为肠道干细胞中的线粒体氧化磷酸化提供乳酸。
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本文引用的文献
1
Interplay between metabolic identities in the intestinal crypt supports stem cell function.
Nature. 2017 Mar 16;543(7645):424-427. doi: 10.1038/nature21673. Epub 2017 Mar 8.
2
Reg4+ deep crypt secretory cells function as epithelial niche for Lgr5+ stem cells in colon.
Proc Natl Acad Sci U S A. 2016 Sep 13;113(37):E5399-407. doi: 10.1073/pnas.1607327113. Epub 2016 Aug 29.
3
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors.
Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.
4
Dietary and metabolic control of stem cell function in physiology and cancer.
Cell Stem Cell. 2014 Mar 6;14(3):292-305. doi: 10.1016/j.stem.2014.02.008.
5
Nutrient-sensing pathways and metabolic regulation in stem cells.
J Cell Biol. 2013 Oct 14;203(1):23-33. doi: 10.1083/jcb.201303110.
6
mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake.
Nature. 2012 Jun 28;486(7404):490-5. doi: 10.1038/nature11163.
7
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.
Cell Metab. 2011 Nov 2;14(5):623-34. doi: 10.1016/j.cmet.2011.09.013.
8
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts.
Nature. 2011 Jan 20;469(7330):415-8. doi: 10.1038/nature09637. Epub 2010 Nov 28.
9
The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.
Cell Stem Cell. 2010 Sep 3;7(3):380-90. doi: 10.1016/j.stem.2010.07.011.
10
Coordinated changes of mitochondrial biogenesis and antioxidant enzymes during osteogenic differentiation of human mesenchymal stem cells.
Stem Cells. 2008 Apr;26(4):960-8. doi: 10.1634/stemcells.2007-0509. Epub 2008 Jan 24.
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