Hubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.
Cell Res. 2017 Jul;27(7):851-852. doi: 10.1038/cr.2017.59. Epub 2017 Apr 21.
Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.
单个 Lgr5 肠道干细胞（ISCs）可在体外扩增为肠上皮类器官或“迷你肠道”，这是一种自我组织的细胞结构，可再现肠道分化程序；潘氏细胞构成了肠道干细胞的龛位，分泌干细胞生长信号，因此对这一过程至关重要。在最近发表在《自然》杂志上的一篇论文中，Rodríguez-Colman 等人描述了潘氏细胞如何支持 ISC 的代谢状态。
