超越生长信号：潘氏细胞在代谢上支持 ISCs。
Beyond growth signaling: Paneth cells metabolically support ISCs.
机构信息
Hubrecht Institute, Royal Academy of Arts and Science (KNAW) and University Medical Centre Utrecht, Uppsalalaan 8, 3584CT, Utrecht, The Netherlands.
出版信息
Cell Res. 2017 Jul;27(7):851-852. doi: 10.1038/cr.2017.59. Epub 2017 Apr 21.
Abstract
Single Lgr5 intestinal stem cells (ISCs) can be expanded in vitro into epithelial organoids or "mini-guts", self-organizing cellular structures that recreate the intestinal differentiation program; Paneth cells, which constitute the intestinal stem cell niche, secrete stem cell growth signals, and are thus essential for this process. In a recent paper published in Nature, Rodríguez-Colman et al. describe how Paneth cells may be supporting the metabolic state of ISCs.
摘要
单个 Lgr5 肠道干细胞（ISCs）可在体外扩增为肠上皮类器官或“迷你肠道”，这是一种自我组织的细胞结构，可再现肠道分化程序；潘氏细胞构成了肠道干细胞的龛位，分泌干细胞生长信号，因此对这一过程至关重要。在最近发表在《自然》杂志上的一篇论文中，Rodríguez-Colman 等人描述了潘氏细胞如何支持 ISC 的代谢状态。
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