生理与癌症中干细胞功能的饮食与代谢调控
Dietary and metabolic control of stem cell function in physiology and cancer.
作者信息
Mihaylova Maria M, Sabatini David M, Yilmaz Ömer H
机构信息
Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA.
Whitehead Institute for Biomedical Research, Cambridge, MA 02142 USA; Howard Hughes Medical Institute, MIT, Cambridge, MA 02139, USA; Broad Institute of Harvard and MIT, Seven Cambridge Center, Cambridge, MA 02142, USA; The David H. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA 02139, USA; Department of Biology, MIT, Cambridge, MA 02139, USA.
出版信息
Cell Stem Cell. 2014 Mar 6;14(3):292-305. doi: 10.1016/j.stem.2014.02.008.
Organismal diet has a profound impact on tissue homeostasis and health in mammals. Adult stem cells are a keystone of tissue homeostasis that alters tissue composition by balancing self-renewal and differentiation divisions. Because somatic stem cells may respond to shifts in organismal physiology to orchestrate tissue remodeling and some cancers are understood to arise from transformed stem cells, there is a likely possibility that organismal diet, stem cell function, and cancer initiation are interconnected. Here we will explore the emerging effects of diet on nutrient-sensing pathways active in mammalian tissue stem cells and their relevance to normal and cancerous growth.
生物体的饮食对哺乳动物的组织稳态和健康有着深远影响。成体干细胞是组织稳态的关键要素，它通过平衡自我更新和分化分裂来改变组织组成。由于体细胞干细胞可能会对生物体生理变化做出反应，从而协调组织重塑，并且已知一些癌症源于转化的干细胞，所以生物体饮食、干细胞功能和癌症发生之间很有可能存在相互联系。在此，我们将探讨饮食对哺乳动物组织干细胞中活跃的营养感应通路的新影响，以及它们与正常生长和癌症生长的相关性。
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