可乐定对大鼠脑片高钾诱发去甲肾上腺素释放的抑制作用的年龄相关性变化。

Age related changes in the inhibitory effect of clonidine on high K+-evoked noradrenaline release from brain slices of rats.

作者信息

Qi S B, Nomura Y

机构信息

Department of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.

出版信息

J Pharmacobiodyn. 1988 Jul;11(7):483-5. doi: 10.1248/bpb1978.11.483.

DOI:10.1248/bpb1978.11.483

PMID:2846818

Abstract

The effects of clonidine on a high K+-induced release of noradrenaline (NA) were studied in 70-d- and 2-year-old rats. Treatment with 0.1 and 1.0 microM clonidine significantly (p less than 0.01) inhibited 20 mM KCl-evoked L-[3H]NA release from cerebral cortical slices in 70-d-old rats. The amounts of high K+-evoked L-[3H]NA release were markedly decreased at 2 years, compared to that at 70 d. In addition, the inhibitory effects of clonidine on high K+-evoked L-[3H]NA release were no longer observed in 2-year-old animals. These results suggested that presynaptic functions, including the modulation of NA release by alpha 2-adrenoceptors, could become low in the brains of the 2-year-old rats.

摘要

研究了可乐定对70日龄和2岁大鼠高钾诱导的去甲肾上腺素（NA）释放的影响。用0.1和1.0微摩尔可乐定处理可显著（p<0.01）抑制70日龄大鼠大脑皮层切片中20毫摩尔氯化钾诱发的L-[3H]NA释放。与70日龄时相比，2岁时高钾诱发的L-[3H]NA释放量明显减少。此外，在2岁动物中不再观察到可乐定对高钾诱发的L-[3H]NA释放的抑制作用。这些结果表明，包括α2-肾上腺素能受体对NA释放的调节在内的突触前功能在2岁大鼠的大脑中可能会降低。