蒂拉文菌素W-Z₇，源自海洋真菌蒂拉维链霉菌UST030930-004的新型防污蒂拉文菌素
Thielavins W-Z₇, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004.
作者信息
Han Zhuang, Li Yong-Xin, Liu Ling-Li, Lu Liang, Guo Xian-Rong, Zhang Xi-Xiang, Zhang Xiao-Yong, Qi Shu-Hua, Xu Ying, Qian Pei-Yuan
机构信息
Institute of Deep-sea Science and Engineering, Chinese Academy of Sciences, 28 Luhuitou Road, Sanya 572000, China.
Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
出版信息
Mar Drugs. 2017 Apr 29;15(5):128. doi: 10.3390/md15050128.
Eleven new depsides-thielavins W-Z (-) and thielavins Z₁-Z₇ (-)-and also four known thielavins-A, H, J, and K (-)-were isolated from the ethyl acetate extract of a marine-derived fungal strain sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle (=) . The results showed that compounds 1-3 and 6-13 were active, with EC values ranging from 2.95 ± 0.59 to 69.19 ± 9.51 μM, respectively. The inhibitive effect of compounds - and was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.
从海洋来源的真菌菌株UST030930-004的乙酸乙酯提取物中分离出11种新的缩酚酸类化合物——硫代黄素W-Z（-）和硫代黄素Z₁-Z₇（-），以及4种已知的硫代黄素——A、H、J和K（-）。对所有这些化合物进行了针对藤壶（=）无节幼虫的防污活性评估。结果表明，化合物1-3和6-13具有活性，其半数有效浓度（EC）值分别为2.95±0.59至69.19±9.51μM。化合物-和的抑制作用是可逆的。这是首次描述硫代黄素对藤壶无节幼虫的防污活性。
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