Hansen Martin Rune Hassan, Jørs Erik, Lander Flemming, Condarco Guido, Debes Fróði, Bustillos Noemi Tirado, Schlünssen Vivi
Danish Ramazzini Centre, Section for Environment, Work and Health, Department of Public Health, Aarhus University, Aarhus, Denmark.
Department of Occupational Medicine, Odense University Hospital, Odense, Denmark.
Environ Health Insights. 2017 Mar 29;11:1178630217700628. doi: 10.1177/1178630217700628. eCollection 2017.
Pyrethroid pesticides have been suggested to be a cause of Parkinson disease and other neurodegenerative diseases. To investigate this, a cross-sectional study was conducted among 120 Bolivian public health vector program spray men, primarily exposed to pyrethroids. Pesticide exposure and central nervous system (CNS) symptoms were determined by a structured interview, whereas neuromotor and neurocognitive performance was assessed using the computerized Behavioral Assessment and Research System and CATSYS system. Individuals exposed to higher levels reported significantly more CNS symptoms (adjusted odds ratio per quintile of cumulative exposure = 2.01 [1.22-3.31]). There was no association seen between pyrethroid exposure and neuromotor performance. Higher spraying intensity was associated with significantly worse neurocognitive performance in structural equation models (adjusted β per quintile = -0.405 [-0.660 to -0.150]), and workers only exposed to pyrethroids performed worse than workers also exposed to other pesticides (adjusted β = -1.344 [-2.224 to -0.464]). Chronic pyrethroid exposure may cause deterioration in neurocognitive performance, and exposure control is recommended.
拟除虫菊酯类农药被认为是帕金森病和其他神经退行性疾病的一个病因。为对此进行调查，在120名主要接触拟除虫菊酯类农药的玻利维亚公共卫生病媒防治项目喷雾作业人员中开展了一项横断面研究。通过结构化访谈确定农药暴露情况和中枢神经系统（CNS）症状，而使用计算机化行为评估与研究系统及CATSYS系统评估神经运动和神经认知表现。暴露于较高水平的个体报告的CNS症状明显更多（累积暴露每五分位数的校正比值比=2.01[1.22 - 3.31]）。未发现拟除虫菊酯暴露与神经运动表现之间存在关联。在结构方程模型中，较高的喷洒强度与明显更差的神经认知表现相关（每五分位数的校正β=-0.405[-0.660至-0.150]），且仅接触拟除虫菊酯类农药的工人比同时接触其他农药的工人表现更差（校正β=-1.344[-2.224至-0.464]）。长期接触拟除虫菊酯类农药可能导致神经认知表现恶化，建议进行暴露控制。
