Eisenhauer T, Talartschik J, Quentin E, Kreutzfeldt W, Scheler F
Abteilung Nephrologie und Rheumatologia, Medizinische Universitätsklinik Göttingen.
Klin Wochenschr. 1988 Sep 15;66(18):940-5. doi: 10.1007/BF01728958.
ANP and c-GMP concentrations in 7 patients with chronic renal failure (CRF) undergoing regular hemofiltration (HF) were determined. After switching to hemodialysis (HD) under identical ultrafiltration and treatment time no significant difference of the ANP and c-GMP profiles was detected, suggesting that the type of treatment does not affect ANP and c-GMP plasma levels. In both procedures a continuous decrease of ANP and c-GMP was observed. Head down tilting to compensate hypotension during HD was immediately followed by an increase in ANP and c-GMP during ultrafiltration. An acute onset of tachyarrhythmia absoluta during HD was also accompanied by a rise in ANP plasma concentrations. This demonstrates that ANP secretion is not altered in patients with CRF. Since ANP plasma levels closely correlate with intravascular volume, periodic determination of this hormone in HD/HF patients may provide diagnostic information to detect volume overload.
测定了7例接受常规血液滤过（HF）的慢性肾衰竭（CRF）患者的心房钠尿肽（ANP）和环磷酸鸟苷（c-GMP）浓度。在相同超滤量和治疗时间下转换为血液透析（HD）后，未检测到ANP和c-GMP水平有显著差异，这表明治疗方式不影响血浆中ANP和c-GMP水平。在这两种治疗过程中均观察到ANP和c-GMP持续下降。HD期间头低位倾斜以补偿低血压，紧接着在超滤期间ANP和c-GMP升高。HD期间急性发作的绝对快速心律失常也伴有ANP血浆浓度升高。这表明CRF患者的ANP分泌未改变。由于ANP血浆水平与血管内容量密切相关，定期测定HD/HF患者的这种激素可能为检测容量超负荷提供诊断信息。
