Crozier I G, Nicholls M G, Ikram H, Espiner E A, Yandle T G, Jans S
Hypertension. 1986 Jun;8(6 Pt 2):II11-5. doi: 10.1161/01.hyp.8.6_pt_2.ii11.
Although it is assumed that the human heart secretes atrial peptides, direct proof is not available. We therefore measured immunoreactive atrial natriuretic peptide levels in coronary sinus blood and simultaneously in femoral arterial and venous blood from patients before and during stepwise incremental atrial pacing of up to 200 beats per minute. Since the fate of circulating atrial peptides is unknown, we also measured immunoreactive atrial natriuretic peptide concentrations in arterial and venous blood across the liver, kidney, lower limb, and lung in patients undergoing cardiological investigation. Peptide levels in coronary sinus blood were higher than in samples from the femoral artery or vein. As the heart rate was accelerated by atrial pacing, peptide concentrations increased in coronary sinus blood and to a lesser extent in peripheral samples. Whereas the levels in venous blood draining the liver, kidney, and lower limb were approximately 50% of those in arterial blood, concentrations were similar in samples drawn simultaneously from the pulmonary artery and the aorta. These results show that the human heart produces immunoreactive atrial natriuretic peptide and that secretion increases with atrial tachycardia. The liver, kidney, and lower limb remove the peptide from arterial blood, but there is little change in its concentration during circulation of blood through the lungs.
尽管人们认为人类心脏会分泌心房肽，但尚无直接证据。因此，我们测量了患者在逐步递增心房起搏直至每分钟200次心跳之前和期间，冠状窦血以及同时股动脉和静脉血中免疫反应性心房利钠肽水平。由于循环中心房肽的去向未知，我们还测量了接受心脏检查患者肝脏、肾脏、下肢和肺部动脉血和静脉血中免疫反应性心房利钠肽浓度。冠状窦血中的肽水平高于股动脉或静脉血样本中的水平。随着心房起搏使心率加快，冠状窦血中的肽浓度增加，外周样本中的肽浓度增加程度较小。流经肝脏、肾脏和下肢的静脉血中的水平约为动脉血中水平的50%，而同时从肺动脉和主动脉采集的样本中的浓度相似。这些结果表明，人类心脏会产生免疫反应性心房利钠肽，且分泌量会随着房性心动过速而增加。肝脏、肾脏和下肢会从动脉血中清除该肽，但在血液流经肺部的过程中其浓度几乎没有变化。
