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Commentary: A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin Treatment of Weight Gain Associated with Initiation of Atypical Antipsychotic Therapy in Children and Adolescents.评论：二甲双胍治疗儿童和青少年非典型抗精神病药物治疗起始相关体重增加的随机、双盲、安慰剂对照试验。
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1
Psychological consequences of childhood obesity: psychiatric comorbidity and prevention.儿童肥胖的心理后果：精神疾病共病与预防
Adolesc Health Med Ther. 2016 Nov 14;7:125-146. doi: 10.2147/AHMT.S101631. eCollection 2016.
2
Metformin for Treatment of Overweight Induced by Atypical Antipsychotic Medication in Young People With Autism Spectrum Disorder: A Randomized Clinical Trial.二甲双胍治疗自闭症谱系障碍青少年使用非典型抗精神病药物引起的超重：一项随机临床试验。
JAMA Psychiatry. 2016 Sep 1;73(9):928-37. doi: 10.1001/jamapsychiatry.2016.1232.
3
Metformin in an Adolescent with Significant Weight Gain.二甲双胍用于一名体重显著增加的青少年患者
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):589-92. doi: 10.1089/cap.2015.29022.bjc.
4
Metformin for Weight Gain and Metabolic Abnormalities Associated With Antipsychotic Treatment: Meta-Analysis of Randomized Placebo-Controlled Trials.二甲双胍用于抗精神病药物治疗相关的体重增加和代谢异常：随机安慰剂对照试验的荟萃分析。
J Clin Psychopharmacol. 2015 Oct;35(5):499-509. doi: 10.1097/JCP.0000000000000392.
5
Improving metabolic parameters of antipsychotic child treatment (IMPACT) study: rationale, design, and methods.改善抗精神病药物儿童治疗的代谢参数（IMPACT）研究：原理、设计和方法。
Child Adolesc Psychiatry Ment Health. 2013 Aug 15;7(1):31. doi: 10.1186/1753-2000-7-31.
6
Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review.抗精神病药治疗儿童和青少年的体重增加和体重指数升高：批判性综述。
Eur Child Adolesc Psychiatry. 2013 Aug;22(8):457-79. doi: 10.1007/s00787-013-0399-5. Epub 2013 Mar 17.
7
Associations between obesity and comorbid mental health, developmental, and physical health conditions in a nationally representative sample of US children aged 10 to 17.在一个具有全国代表性的美国 10 至 17 岁儿童样本中，肥胖与合并的心理健康、发育和身体健康状况之间的关联。
Acad Pediatr. 2013 Jan-Feb;13(1):6-13. doi: 10.1016/j.acap.2012.10.007. Epub 2012 Nov 30.
8
Acute and maintenance effects of non-pharmacologic interventions for antipsychotic associated weight gain and metabolic abnormalities: a meta-analytic comparison of randomized controlled trials.非药物干预对抗精神病药相关体重增加和代谢异常的急性和维持效果：随机对照试验的荟萃分析比较。
Schizophr Res. 2012 Sep;140(1-3):159-68. doi: 10.1016/j.schres.2012.03.017. Epub 2012 Jul 3.
9
A systematic review of metformin to limit weight-gain with atypical antipsychotics.二甲双胍限制非典型抗精神病药引起体重增加的系统评价。
J Clin Pharm Ther. 2011 Oct;36(5):537-45. doi: 10.1111/j.1365-2710.2011.01255.x. Epub 2011 Mar 21.
10
Effects of metformin on body weight and body composition in obese insulin-resistant children: a randomized clinical trial.二甲双胍对肥胖胰岛素抵抗儿童体重和身体成分的影响：一项随机临床试验。
Diabetes. 2011 Feb;60(2):477-85. doi: 10.2337/db10-1185. Epub 2011 Jan 12.

Commentary: A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin Treatment of Weight Gain Associated with Initiation of Atypical Antipsychotic Therapy in Children and Adolescents.

作者信息

Goltz Jeffrey Samuel, Rice Timothy Reynolds

机构信息

Psychiatry, Mount Sinai St. Luke's-West Hospital, New York City, NY, USA.

Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

出版信息

Front Psychiatry. 2017 Apr 19;8:59. doi: 10.3389/fpsyt.2017.00059. eCollection 2017.

DOI:10.3389/fpsyt.2017.00059
PMID:28469583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5395636/
Abstract
摘要