肥胖、心力衰竭与肥胖悖论
Obesity, Heart Failure, and Obesity Paradox.
作者信息
Hamzeh Nikoo, Ghadimi Fatemeh, Farzaneh Rojin, Hosseini Seyed Kianoosh
机构信息
Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Tehran Heart Cent. 2017 Jan;12(1):1-5.
Abstract
The incidence and prevalence of obesity are fast increasing worldwide. Various indices have been used to measure and assess obesity. The body mass index (BMI) is the most common and practical of these indices. Overweight and obesity exert considerable adverse effects on the cardiovascular system. These effects are mediated through various neurohormonal and cytokine pathways, most of which are inflammatory mediators. Systolic and / or diastolic heart failure is more prevalent among obese and overweight individuals than among normal weight people. The concept of the "obesity paradox" has been proposed by some previously published studies, in which the prognosis of obese patients with established cardiovascular diseases, especially heart failure, is better than that of their leaner counterparts. In this review, we discuss the obesity paradox and its possible pathophysiologic mechanisms.
摘要
肥胖症的发病率和患病率在全球范围内正在迅速上升。人们使用了各种指标来测量和评估肥胖症。体重指数（BMI）是这些指标中最常用且实用的。超重和肥胖对心血管系统产生相当大的不良影响。这些影响是通过各种神经激素和细胞因子途径介导的，其中大多数是炎症介质。收缩期和/或舒张期心力衰竭在肥胖和超重个体中比在正常体重人群中更为普遍。一些先前发表的研究提出了“肥胖悖论”的概念，即已确诊患有心血管疾病，尤其是心力衰竭的肥胖患者，其预后比体型较瘦的患者更好。在这篇综述中，我们讨论了肥胖悖论及其可能的病理生理机制。
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