来自濒危针叶树皱叶罗汉松的抗神经炎症二萜类化合物。
Anti-neuroinflammatory diterpenoids from the endangered conifer Podocarpus imbricatus.
作者信息
Hu Chang-Ling, Xiong Juan, Xiao Chen-Xi, Tang Yu, Ma Guang-Lei, Wan Jiang, Hu Jin-Feng
机构信息
a Department of Natural Products Chemistry , School of Pharmacy, Fudan University , Shanghai 201203 , China.
b Department of Pharmacology , School of Pharmacy, Fudan University , Shanghai 201203 , China.
出版信息
J Asian Nat Prod Res. 2018 Feb;20(2):101-108. doi: 10.1080/10286020.2017.1319821. Epub 2017 May 4.
Ten diterpenoids including three new abietanes (1-3) were isolated from the twigs and needles of Podocarpus imbricatus, an endangered conifer growing in a Cantonese garden. The new structures were established by means of spectroscopic methods. Among the isolates, 3β-hydroxy-abieta-8,11,13-trien-7-one (5), decandrin G (6), and 7,15-pimaradien-18-oic acid (8) showed significant anti-neuroinflammatory activities by inhibiting the overproduction of nitric oxide (NO) in lipopolysaccharide (LPS)-stimulated murine BV-2 microglial cells, with IC values of 3.7, 11.1, and 4.5 μM, respectively.
从生长于广州某花园的濒危针叶树鸡毛松的嫩枝和针叶中分离出10种二萜类化合物，其中包括3种新的枞烷型二萜（1-3）。通过光谱方法确定了新的结构。在分离出的化合物中，3β-羟基枞-8,11,13-三烯-7-酮（5）、十烷素G（6）和7,15-海松二烯-18-酸（8）通过抑制脂多糖（LPS）刺激的小鼠BV-2小胶质细胞中一氧化氮（NO）的过量产生，表现出显著的抗神经炎症活性，IC值分别为3.7、11.1和4.5 μM。
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