State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People's Republic of China.
J Nat Prod. 2013 Feb 22;76(2):256-64. doi: 10.1021/np300772e. Epub 2013 Jan 17.
Three new abietane diterpenoids, isoabietenins A-C (1-3), and 13 new ent-kauranoids, tenuifolins A-M (4-16), along with four known compounds (17-20), were isolated from the aerial parts of Isodon tenuifolius. The structures of the new metabolites were established on the basis of detailed spectroscopic analysis. The absolute configurations of 1, 15, and 16 were confirmed by single-crystal X-ray diffraction. Selected compounds were evaluated for their cytotoxicity against a small panel of human tumor cell lines, and some compounds showed inhibitory effects. Furthermore, several isolates exhibited inhibitory activity against nitric oxide production in LPS-activated RAW264.7 macrophages.
从纤细吴茱萸的地上部分分离得到三个新的扁柏烷二萜，即异扁柏素 A-C（1-3），以及 13 个新的贝壳杉烷二萜，即纤细吴茱萸内酯 A-M（4-16），此外还有四个已知化合物（17-20）。基于详细的光谱分析确定了新代谢产物的结构。通过单晶 X 射线衍射确定了 1、15 和 16 的绝对构型。对部分化合物进行了人肿瘤细胞系的细胞毒性评价，部分化合物表现出抑制作用。此外，几种分离物对 LPS 激活的 RAW264.7 巨噬细胞中的一氧化氮产生具有抑制活性。
