Arriagada R, Le Chevalier T
Institut Gustave-Roussy, Villejuif.
Presse Med. 1988 Oct 22;17(36):1851-6.
Small cell lung cancer is one of the most chemo and radiosensitive adult solid malignancies. The effects of treatment should be evaluated according to standardized rules to ensure reproducibility. Recent randomized clinical trials have shown that combined chemo and radiotherapy can improve survival. A 5-year survival rate of 20 per cent can be obtained for an initially limited disease. However, further improvement of results requires optimized drug combinations and multimodality approaches as well as a better integration of new biological concepts in therapeutic trials.
小细胞肺癌是对化疗和放疗最敏感的成人实体恶性肿瘤之一。应根据标准化规则评估治疗效果，以确保可重复性。近期的随机临床试验表明，化疗联合放疗可提高生存率。对于初始局限期疾病，可获得20%的5年生存率。然而，要进一步改善治疗结果，需要优化药物组合和多模式治疗方法，并在治疗试验中更好地整合新的生物学理念。
