Transbøl I, Christiansen C, Hornum I
Acta Med Scand Suppl. 1979;624:69-72. doi: 10.1111/j.0954-6820.1979.tb00722.x.
Simultaneous determinations of serum total calcium(TOCa), protein corrected total calcium (TOCac), ultrafiltrable calcium (UFCa) and ionised calcium (Ca++) were undertaken in 63 controls and in 76 patients with primary hyperparathyroidism. Raised levels of Ca++ were used as one criterion of the diagnosis which was confirmed by operation in all. For the purpose of estimating the relative value of TOCa and TOCac in the detection of mild hyperparathyroidism we selected all patients with TOCa values below 3.00 mmol/l (n = 46). As a group these patients turned out to be mildly hypoproteinaemic (p less than 0.01), probably because of high age and complicating conditions. Further subdivision of this group into frank hypercalcaemia, borderline hypercalcaemia and normocalcaemia was undertaken according to the respective 99% and 95% confidence limits of normal. Twenty-seven patients were classified as frankly hypercalcaemic by TOCa as well as by TOCac. The distribution of the remaining 19 patients within the three categories was 1:6:12 as judged from TOCa while TOCac gave a better distinction from normal, 9:4:6 (p less than 0.01). This compared well with the classification obtained by UFCa, 10:5:4. It is concluded that TOCac is definitely advantageous to TOCa in the detection of hypercalcaemia in mild primary hyperparathyroidism.
对63名对照者和76名原发性甲状旁腺功能亢进患者同时进行了血清总钙（TOCa）、蛋白校正总钙（TOCac）、超滤钙（UFCa）和离子钙（Ca++）的测定。Ca++水平升高被用作诊断标准之一，所有患者均通过手术确诊。为了评估TOCa和TOCac在检测轻度甲状旁腺功能亢进中的相对价值，我们选择了所有TOCa值低于3.00 mmol/l的患者（n = 46）。作为一组，这些患者结果显示为轻度低蛋白血症（p < 0.01），可能是由于高龄和合并症。根据正常范围的各自99%和95%置信限，将该组进一步细分为明显高钙血症、临界高钙血症和正常血钙血症。27名患者通过TOCa和TOCac均被分类为明显高钙血症。从TOCa判断，其余19名患者在这三个类别中的分布为1:6:12，而TOCac与正常的区分更好，为9:4:6（p < 0.01）。这与通过UFCa获得的分类结果10:5:4相比良好。得出的结论是，在检测轻度原发性甲状旁腺功能亢进的高钙血症方面，TOCac绝对优于TOCa。
