三硅氧烷磷酸胆碱双层分析。
Analysis of Trisiloxane Phosphocholine Bilayers.
机构信息
Department of Chemistry and Centre for Biotechnology, Brock University , St. Catharines, Ontario L2S 3A1, Canada.
Institute of Molecular Biosciences, Biophysics Division, University of Graz, NAWI Graz , Graz, 8010, Austria.
出版信息
Langmuir. 2017 May 23;33(20):4948-4953. doi: 10.1021/acs.langmuir.6b04162. Epub 2017 May 11.
Abstract
We have synthesized unique siloxane phosphocholines and characterized their aggregates in aqueous solution. The siloxane phosphocholines form nearly monodisperse vesicles in aqueous solution without the need for secondary extrusion processes. The area/lipid, lipid volume, and bilayer thickness were determined from small-angle X-ray scattering experiments. The impetus for the spontaneous formation of unilamellar vesicles by these compounds is discussed.
摘要
我们合成了独特的硅氧烷磷胆碱，并对其在水溶液中的聚集物进行了表征。硅氧烷磷胆碱在水溶液中形成几乎单分散的囊泡，而无需二次挤出过程。从小角度 X 射线散射实验中确定了面积/脂质、脂质体积和双层厚度。讨论了这些化合物自发形成单层囊泡的动力。
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