Kubo Tadahiko, Furuta Taisuke, Johan Muhammad P, Yoshizuka Masaaki, Ochi Mitsuo, Adachi Nobuo
Department of Orthopaedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.
Medicine (Baltimore). 2017 May;96(18):e6824. doi: 10.1097/MD.0000000000006824.
Histologically conventional osteosarcoma, once metastasized to the lung, generally causes a rapid and fatal outcome. Osteosarcoma metastasis to the gastrointestinal tract is extremely rare.We report herein a case of osteoblastic osteosarcoma with exceptionally unique features: sporadic lung metastases and delayed metastases to the stomach and the jejunum with long-term survival. She received multiple operations and chemotherapies, but consequently died of peritoneal dissemination. A review of the literature on osteosarcoma metastasis to the gastrointestinal tract is presented.This patient was very unusual in terms of a long-term survival and metastatic sites, suggesting the importance of vigilance and thorough follow-up for patients with conventional osteosarcoma.
组织学上的传统骨肉瘤一旦转移至肺部,通常会导致迅速且致命的后果。骨肉瘤转移至胃肠道极为罕见。我们在此报告一例具有异常独特特征的成骨性骨肉瘤病例:散发性肺转移以及延迟转移至胃和空肠且长期存活。她接受了多次手术和化疗,但最终死于腹膜播散。本文对骨肉瘤转移至胃肠道的文献进行了综述。该患者在长期存活和转移部位方面非常特殊,提示对于传统骨肉瘤患者保持警惕并进行全面随访的重要性。