脑啡肽对泌乳大鼠乳腺的影响：体外研究

Effects of enkephalin on lactating rat mammary gland: in vitro studies.

作者信息

Conde E, Lavandero S, Puente J, Sapag-Hagar M

机构信息

Departamento de Bioquimica y Biologia Molecular, Facultad de Ciencias Quimicas y Farmaceuticas, Universidad de Chile, Santiago.

出版信息

Res Commun Chem Pathol Pharmacol. 1988 Sep;61(3):353-63.

PMID:2847264

Abstract

We studied the in vitro effects of methionine-enkephalin and D-ala-methionine-enkephalin upon lactating rat mammary gland milk product's secretion and intracellular cyclic AMP levels. Our results show that the lactating gland does not respond to the action of these peptides and suggest that during this period this tissue lacks enkephalin receptors.

摘要

我们研究了甲硫氨酸脑啡肽和D-丙氨酸-甲硫氨酸脑啡肽对泌乳大鼠乳腺乳汁分泌及细胞内环磷酸腺苷（cAMP）水平的体外作用。我们的结果表明，泌乳期乳腺对这些肽的作用无反应，提示在此期间该组织缺乏脑啡肽受体。