铜催化的 Friedel-Crafts 烷基化/环化反应序列：一种构建功能化吡咯并[1,2-a]吲哚螺环氧化吲哚和 9H-吡咯并[1,2-a]吲哚的方法。
A Copper-Catalyzed Friedel-Crafts Alkylation/Cyclization Sequence: an Approach to Functionalized Pyrrolo[1,2-a]indole Spirooxindoles and 9H-Pyrrolo[1,2-a]indoles.
机构信息
Institute of Fine Chemistry and Engineering, College of Chemistry and Chemical Engineering, Henan University , Kaifeng 475004, China.
出版信息
J Org Chem. 2017 Jun 2;82(11):5669-5677. doi: 10.1021/acs.joc.7b00488. Epub 2017 May 10.
PMID:28472885
Abstract
An efficient Cu(OTf)-catalyzed Friedel-Crafts alkylation/cyclizaiton sequence of 3-substituted indoles with isatin-derived oxodienes was developed, and a series of structurally complex and diverse pyrrolo[1,2-a]indole spirooxindoles were first obtained in up to 99% yields. This protocol proved to be quite general and was also robust for the synthesis of 9H-pyrrolo[1,2-a]indoles.
摘要
发展了一种高效的三取代吲哚与色酮衍生的氧二烯的 Friedel-Crafts 烷基化/环化序列，首次通过该序列以高达 99%的收率得到了一系列结构复杂多样的吡咯并[1,2-a]吲哚螺环氧化吲哚。该方法具有广泛的适用性，对于 9H-吡咯并[1,2-a]吲哚的合成也具有很好的稳健性。
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