一种用于构建香豆素稠合的9H-吡咯并[1,2-a]吲哚的铜催化串联反应。
A copper-catalyzed tandem reaction for the construction of coumarin fused 9H-pyrrolo[1,2-a]indoles.
作者信息
Jin Shao-Jing, Guo Jiao-Mei, Zhu Yan-Shuo, Wang Qi-Lin, Bu Zhan-Wei
机构信息
College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004, China.
出版信息
Org Biomol Chem. 2017 Oct 25;15(41):8729-8737. doi: 10.1039/c7ob02307c.
An efficient copper-catalyzed Friedel-Crafts alkylation/cyclization/isomerization sequence of 3-arylcarbonyl coumarins and 3-methyl indole was developed to afford a wide range of functionalized coumarin fused 9H-pyrrolo[1,2-a]indoles, which feature a 6-6-5-5-6 pentacyclic core, in 34-99% yields. Moreover, gram-scale experiment and chemical transformations were conducted to demonstrate the synthetic value of this protocol.
开发了一种高效的铜催化的3-芳基羰基香豆素与3-甲基吲哚的傅克烷基化/环化/异构化反应序列，以34-99%的产率得到了一系列具有6-6-5-5-6五环核心的官能团化香豆素稠合9H-吡咯并[1,2-a]吲哚。此外，还进行了克级实验和化学转化，以证明该方法的合成价值。
Zotero 插件