Farjanikish Ghasem, Oryan Ahmad
Department of Pathobiology, Faculty of Veterinary Medicine, Lorestan University, Khorram Abad, Iran.
Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Vet Res Forum. 2017 Winter;8(1):81-84. Epub 2017 Mar 15.
Leydig cell tumor as a sex-cord stromal tumor is a relatively uncommon ovarian tumor in bitch. A 10-year-old female German Shepherd dog was presented because of protrusion of a large tumor-like mass of 16 × 14 × 7 cm in dimensions from her vagina. After stabilization of the patient, the mass was removed surgically and concurrent ovariohysterectomy was also performed. Macroscopically, the healthy tissue of the right ovary was totally replaced by a homogeneous, brown and firm mass. The neoplasm was well-circumscribed and nodular and it was clearly demarcated from the healthy tissue. Histological examination revealed the presence of solid sheets and acinar structures composed of polyhedral to elongated cells. The neoplastic cells had large, eosinophilic, and vacuolated cytoplasms with round to oval nuclei and expressed vimentin on immunohistochemical examination. These gross, microscopic and immuno-histochemical features are characteristics of ovarian Leydig cell tumor.
睾丸间质细胞瘤作为一种性索间质肿瘤，是母犬中相对罕见的卵巢肿瘤。一只10岁的雌性德国牧羊犬因从阴道突出一个大小为16×14×7厘米的巨大肿瘤样肿块而就诊。在患者病情稳定后，手术切除了肿块，并同时进行了卵巢子宫切除术。肉眼可见，右侧卵巢的健康组织完全被一个均匀、棕色且质地坚实的肿块所取代。肿瘤边界清晰，呈结节状，与健康组织界限分明。组织学检查显示存在由多面体至细长形细胞组成的实性片层和腺泡结构。肿瘤细胞具有大的、嗜酸性且有空泡的细胞质，核呈圆形至椭圆形，免疫组织化学检查显示其表达波形蛋白。这些大体、显微镜和免疫组织化学特征均为卵巢睾丸间质细胞瘤的特点。
