Nishina Hironobu, Izawa Takeshi, Ozaki Miki, Kuwamura Mitsuru, Yamate Jyoji
Laboratory of Veterinary Pathology, Graduate School of Life and Environmental Sciences, Osaka Prefecture University, 1-58 Rinku-Ourai-Kita, Izumisano, Osaka 598-8531, Japan.
Adventure World AWS Co., Ltd., 2399 Nishimuro-gun, Shirahama-cho, Katada, Wakayama 649-2201, Japan.
J Vet Med Sci. 2017 Oct 20;79(10):1749-1752. doi: 10.1292/jvms.17-0172. Epub 2017 Aug 27.
A white, lobular mass was found in the right ovary of a pregnant Risso's dolphin (Grampus griseus) at necropsy. The mass was unilateral and occupied most of the pre-existing ovarian tissue. Histologically, the mass was composed of diffuse sheets of polyhedral cells with abundant eosinophilic cytoplasm and oval nuclei, separated by fibrous connective tissue. Only a few ovarian follicles were observed at the periphery of the mass. Immunohistochemically, the large eosinophilic cells were positive for vimentin and negative for pan-cytokeratins. Based on the histopathological features, the present case was diagnosed as luteoma. In human medicine, luteoma of pregnancy, a tumor-like proliferative lesion occurring in pregnant women, is well described. In veterinary medicine, luteoma associated with pregnancy has never been described. The present study would provide useful information for understanding the characteristics of luteoma in animals.
在对一头怀孕的里氏海豚（灰海豚）进行尸检时，在其右侧卵巢发现了一个白色的小叶状肿块。该肿块为单侧性，占据了大部分原有的卵巢组织。组织学上，肿块由弥漫性的多面体细胞片组成，这些细胞具有丰富的嗜酸性细胞质和椭圆形细胞核，被纤维结缔组织分隔。在肿块周边仅观察到少数卵巢卵泡。免疫组织化学检测显示，大的嗜酸性细胞波形蛋白呈阳性，泛细胞角蛋白呈阴性。根据组织病理学特征，本病例被诊断为黄体瘤。在人类医学中，妊娠黄体瘤是一种发生在孕妇身上的肿瘤样增殖性病变，已有详细描述。在兽医学中，则从未有过与妊娠相关的黄体瘤的描述。本研究将为了解动物黄体瘤的特征提供有用信息。
