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儿科唾液诊断:适用性、可转化性及局限性

Salivary Diagnostics in Pediatrics: Applicability, Translatability, and Limitations.

作者信息

Hassaneen Mona, Maron Jill L

机构信息

Mother Infant Research Institute at Tufts Medical Center, Boston, MA, USA.

Division of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, Boston, MA, USA.

出版信息

Front Public Health. 2017 Apr 20;5:83. doi: 10.3389/fpubh.2017.00083. eCollection 2017.

Abstract

In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive "omic" analyses of saliva could significantly improve care and enhance health access. In this review, we will highlight novel applications of salivary diagnostics in pediatrics across the "omic" spectrum, including at the genomic, transcriptomic, proteomic, microbiomic, and metabolomic level. The challenges to implementing salivary platforms into care, including the effects of age, diet, and developmental stage on salivary components, will be reviewed. Ultimately, large-scale, multicenter trials must be performed to establish normative biomarker values across the age spectrum to accurately discriminate between health and disease. Only then can salivary diagnostics truly translate into pediatric care.

摘要

在过去十年中,技术进步,再加上人们对唾液告知护理人员口腔健康和全身疾病能力的认识有所提高,催生了唾液诊断平台。然而,这些检测方法大多针对的是更常见于成年人群体的疾病,很大程度上忽视了婴幼儿和儿童,而他们无疑能从用于健康监测的非侵入性评估工具中获益最多。通过对唾液进行全面的“组学”分析来深入了解发育、感染和疾病情况,可能会显著改善医疗护理并增加获得医疗服务的机会。在本综述中,我们将重点介绍唾液诊断在儿科领域跨“组学”范围的新应用,包括基因组、转录组、蛋白质组、微生物组和代谢组水平。我们还将探讨将唾液检测平台应用于医疗护理所面临的挑战,包括年龄、饮食和发育阶段对唾液成分的影响。最终,必须开展大规模、多中心试验,以确定全年龄段的标准化生物标志物值,从而准确区分健康与疾病。只有这样,唾液诊断才能真正应用于儿科护理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0831/5397421/ea5e8522de34/fpubh-05-00083-g001.jpg

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