胞壁酰二肽的多异戊烯基乙酰衍生物的免疫活性。

Immunological activities of multiprenylacetyl derivatives of muramyldipeptides.

作者信息

Azuma I, Saiki I, Iida J, Fukuda T, Kobayashi S

机构信息

Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

出版信息

Vaccine. 1988 Aug;6(4):339-42. doi: 10.1016/0264-410x(88)90180-6.

DOI:10.1016/0264-410x(88)90180-6

PMID:2847438

Abstract

The immunological properties of six kinds of multiprenylacetic acids and six kinds of multiprenylacetyl muramyldipeptide (MDP) derivatives were examined by using experimental models in mice and guinea-pigs. All the multiprenylacetyl MDP derivatives, particularly TMD-232, showed potent adjuvant activity on the circulating antibody formation against bacterial alpha-amylase in mice, and induction of delayed-type hypersensitivity to monoazobenzenearsonate N-acetyl-L-tyrosine in guinea-pigs. All multiprenylacetic acid preparations tested in this study, however, showed no adjuvant activity in these immune systems. Both TMD-17 and TMD-232 entrapped into multilamellar vesicles showed potent host stimulation activity against Sendai virus infection in mice.

摘要

利用小鼠和豚鼠实验模型，对六种多异戊烯基乙酸和六种多异戊烯基乙酰胞壁酰二肽（MDP）衍生物的免疫特性进行了研究。所有多异戊烯基乙酰MDP衍生物，尤其是TMD - 232，对小鼠体内针对细菌α -淀粉酶的循环抗体形成具有强大的佐剂活性，并能诱导豚鼠对单偶氮苯胂酸N -乙酰 - L -酪氨酸产生迟发型超敏反应。然而，本研究中测试的所有多异戊烯基乙酸制剂在这些免疫系统中均未显示出佐剂活性。包裹在多层囊泡中的TMD - 17和TMD - 232对小鼠仙台病毒感染均表现出强大的宿主刺激活性。