烟酸衍生物及其烟酰胺腺嘌呤二核苷酸类似物的佐剂活性和促有丝分裂活性。

Adjuvant and mitogenic activities of niacine derivatives and their NAD-analogs.

作者信息

Saiki I, Tono-oka S, Azuma I

出版信息

Int J Vitam Nutr Res. 1981;51(3):239-46.

Abstract

The effects of niacine derivatives and their corresponding NAD-analogs on the immune response in vivo and in vitro and the mitogenic activity were investigated. The compounds III, IIIa, IV, V and Va act as adjuvants on the production of circulating antibody to bacterial alpha-amylase in guinea pigs when they were immunized as water-in-oil emulsion. All the compounds at 10-micrograms dose can act as adjuvant on the primary immune response to sheep erythrocytes in vitro. However it was shown that all the compounds had slight or no adjuvant activity on the induction of delayed-type hypersensitivity to ABA-N-acetyl-L-tyrosine. The compounds I, Ia and II were mitogenic in normal mouse spleen cells.

摘要

研究了烟酸衍生物及其相应的烟酰胺类似物对体内外免疫反应和促有丝分裂活性的影响。当化合物III、IIIa、IV、V和Va以油包水乳液形式免疫豚鼠时，它们对豚鼠体内抗细菌α-淀粉酶循环抗体的产生具有佐剂作用。所有化合物在10微克剂量时，对体外绵羊红细胞的初次免疫反应都可起到佐剂作用。然而，结果表明，所有这些化合物对ABA-N-乙酰-L-酪氨酸迟发型超敏反应的诱导作用轻微或无佐剂活性。化合物I、Ia和II对正常小鼠脾细胞具有促有丝分裂作用。

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