Boĭchenko M N, Dombrovskiĭ A M, Sivov I G
Zh Mikrobiol Epidemiol Immunobiol. 1988 Jul(7):9-11.
To study the role of cAMP in the virulence of S. typhimurium, cAMP-producing plasmid pTG 4 was transferred to cAMP-deficient S. typhimurium mutant. The transfer of the plasmid enhanced the virulence of the microorganisms due to the increased destruction of macrophages and the intensified multiplication of salmonellae in the spleen of mice.
为研究环磷酸腺苷（cAMP）在鼠伤寒沙门氏菌毒力中的作用，将产生cAMP的质粒pTG 4转移至cAMP缺陷型鼠伤寒沙门氏菌突变体。该质粒的转移增强了微生物的毒力，这是由于巨噬细胞的破坏增加以及沙门氏菌在小鼠脾脏中的增殖加剧。
