Hu Jieping, Wang Gongxian, Sun Ting
Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.
Tumour Biol. 2017 May;39(5):1010428317692259. doi: 10.1177/1010428317692259.
Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression. However, the emerging of castration-resistant prostate cancer reminds us the alteration of androgen receptor, which includes androgen receptor mutation, the formation of androgen receptor variants, and androgen receptor distribution in cancer cells. In this review, we introduce the process of androgen receptor and also its variants' formation, translocation, and function alteration by protein modification or interaction with other pathways. We dissect the roles of androgen receptor in prostate cancer from molecular perspective to provide clues for battling prostate cancer, especially castration-resistant prostate cancer.
雄激素受体在前列腺癌进展中起关键作用，而阻断雄激素受体信号通路的雄激素剥夺疗法是大多数晚期前列腺癌患者延缓癌症进展不可或缺的治疗方法。然而，去势抵抗性前列腺癌的出现提醒我们雄激素受体的改变，这包括雄激素受体突变、雄激素受体变体的形成以及癌细胞中雄激素受体的分布。在本综述中，我们介绍了雄激素受体及其变体的形成、易位以及通过蛋白质修饰或与其他信号通路相互作用导致的功能改变过程。我们从分子角度剖析雄激素受体在前列腺癌中的作用，为对抗前列腺癌尤其是去势抵抗性前列腺癌提供线索。
