Xiang Chuan, Chen Junxia, Fu Panfeng
Department of Orthopedics, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
Department of Cell Biology and Genetics, Chongqing Medical University, Chongqing 400016, China.
Cancers (Basel). 2017 May 5;9(5):44. doi: 10.3390/cancers9050044.
The invasion of cancer cells into surrounding tissue and the vasculature is essential for tumor metastasis. Increasing evidence indicates that hepatocyte growth factor (HGF) induces cancer cell migration and invasion. A broad spectrum of mechanisms underlies cancer cell migration and invasion. Cytoskeletal reorganization is of central importance in the development of the phenotype of cancer cells with invasive behavior. Through their roles in cell mechanics, intracellular trafficking, and signaling, cytoskeleton proteins participate in all essential events leading to cell migration. HGF has been involved in cytoskeleton assembly and reorganization, and its role in regulating cytoskeleton dynamics is still expanding. This review summarizes our current understanding of the role of HGF in regulating cytoskeleton remodeling, distribution, and interactions.
癌细胞侵袭周围组织和脉管系统是肿瘤转移的关键环节。越来越多的证据表明，肝细胞生长因子（HGF）可诱导癌细胞迁移和侵袭。癌细胞迁移和侵袭有着广泛的机制。细胞骨架重组在具有侵袭行为的癌细胞表型发展中至关重要。细胞骨架蛋白通过在细胞力学、细胞内运输和信号传导中的作用，参与导致细胞迁移的所有重要事件。HGF已参与细胞骨架的组装和重组，其在调节细胞骨架动力学方面的作用仍在不断扩展。本文综述了我们目前对HGF在调节细胞骨架重塑、分布和相互作用方面作用的理解。
