Zhang Junliang, Zhang Xue, Zhang Jianbin, Li Moying, Chen Daijie, Wu Tong
a State Key Lab. of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry , Shanghai , PR China.
Nat Prod Res. 2018 May;32(10):1198-1202. doi: 10.1080/14786419.2017.1323212. Epub 2017 May 5.
The study explored the isolation and characterisation of three compounds of high purity salvianolic acid B freeze-dried powder extracted from Salvia miltiorrhiza Bunge. A new salvianolic acid, salvianolic acid V (2) together with two known compounds (3-4) was identified. The antibacterial activity tests showed that compound 2 combined with clinical antibiotics such as Levofloxacin or Colistin sulphate together exhibited potent effects against MRSA or Acinetobacter baumanii. This report has considerably extended our knowledge about the diversity and bioactivity of caffeic acid derivatives from S. miltiorrhiza.
该研究探索了从丹参中提取的高纯度丹酚酸B冻干粉的三种化合物的分离与表征。鉴定出一种新的丹酚酸——丹酚酸V（2）以及两种已知化合物（3 - 4）。抗菌活性测试表明，化合物2与左氧氟沙星或硫酸黏菌素等临床抗生素联合使用时，对耐甲氧西林金黄色葡萄球菌（MRSA）或鲍曼不动杆菌具有显著效果。本报告极大地扩展了我们对丹参中咖啡酸衍生物的多样性和生物活性的认识。
