Ellward Garrett L, Binda Macie E, Dzurny Dominika I, Bucher Michael J, Dees Wren R, Czyż Daniel M
Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32611, USA.
Antibiotics (Basel). 2024 Dec 17;13(12):1220. doi: 10.3390/antibiotics13121220.
Antimicrobial resistance (AMR) is a growing threat that undermines the effectiveness of global healthcare. The Centers for Disease Control and Prevention and the World Health Organization have identified numerous microbial organisms, particularly members of the ESKAPEE pathogens, as critical threats to global health and economic security. Many clinical isolates of these pathogens have become completely resistant to current antibiotics, making treatment nearly impossible. Herbal remedies, such as those found in Traditional Chinese Medicine (TCM), have been practiced for thousands of years and successfully used to treat a wide range of ailments, including infectious diseases. Surprisingly, despite this extensive knowledge of folk medicine, no plant-derived antibacterial drugs are currently approved for clinical use. As such, the objective of this study is to evaluate the antimicrobial properties of extracts derived from TCM plants. This study explores a comprehensive library comprising 664 extracts from 132 distinct TCM plant species for antimicrobial properties against gram-negative () and gram-positive () bacteria using liquid and solid in vitro assays. Intriguingly, our results reveal 17 plant species with potent antimicrobial properties effective primarily against gram-positive organisms, including and . A literature search revealed that nearly 100 purified compounds from the identified TCM plants were previously isolated and confirmed for their antimicrobial properties, collectively inhibiting 45 different bacterial species. Our results indicate that phytobiotics from the identified plants could serve as potential candidates for novel antimicrobials.
抗菌药物耐药性（AMR）是一个日益严重的威胁，它削弱了全球医疗保健的有效性。美国疾病控制与预防中心和世界卫生组织已将众多微生物，特别是ESKAPEE病原体成员，确定为对全球健康和经济安全的重大威胁。这些病原体的许多临床分离株已对目前的抗生素完全耐药，使得治疗几乎不可能。草药疗法，如传统中医（TCM）中发现的那些，已经应用了数千年，并成功用于治疗包括传染病在内的多种疾病。令人惊讶的是，尽管对民间医学有如此广泛的了解，但目前尚无植物源抗菌药物被批准用于临床。因此，本研究的目的是评估源自中药植物的提取物的抗菌特性。本研究使用液体和固体体外试验，探索了一个包含来自132种不同中药植物的664种提取物的综合文库，以检测其对革兰氏阴性菌（）和革兰氏阳性菌（）的抗菌特性。有趣的是，我们的结果显示有17种植物具有强大的抗菌特性，主要对革兰氏阳性菌有效，包括和。文献检索显示，先前已从所鉴定的中药植物中分离出近100种纯化化合物，并证实了它们的抗菌特性，这些化合物共同抑制了45种不同的细菌。我们的结果表明，所鉴定植物中的植物源生物活性物质可作为新型抗菌剂的潜在候选物。
