Schuckit M A, Risch S C, Gold E O
School of Medicine, University of California, San Diego.
Am J Psychiatry. 1988 Nov;145(11):1391-5. doi: 10.1176/ajp.145.11.1391.
Plasma levels of ACTH were evaluated in 18 sons of alcoholics and 18 sons of nonalcoholics before and after they consumed placebo, 0.75 ml/kg of ethanol, and 1.1 ml/kg of ethanol. The analyses revealed significant changes in ACTH levels over time, an effect of ethanol on ACTH overall, and significantly lower ACTH levels in the sons of alcoholics than in the control subjects following the high-dose ethanol challenge. The data corroborate the earlier finding that sons of alcoholics have less intense responses to ethanol and are consistent with the conclusion that changes in cortisol level associated with drinking include a pituitary response as well as effects on the adrenal glands.
在18名酗酒者的儿子和18名非酗酒者的儿子摄入安慰剂、0.75毫升/千克乙醇以及1.1毫升/千克乙醇之前和之后，对他们的促肾上腺皮质激素（ACTH）血浆水平进行了评估。分析显示，ACTH水平随时间有显著变化，乙醇对ACTH总体有影响，并且在高剂量乙醇激发后，酗酒者的儿子的ACTH水平显著低于对照组受试者。这些数据证实了早期的发现，即酗酒者的儿子对乙醇的反应较弱，并且与以下结论一致：与饮酒相关的皮质醇水平变化包括垂体反应以及对肾上腺的影响。
