Schuckit M A, Gold E, Risch C
Am J Psychiatry. 1987 Jul;144(7):854-9. doi: 10.1176/ajp.144.7.854.
The authors evaluated changes in serum prolactin levels as a measure of differences in response to ethanol between 30 healthy, drinking, young adult sons of alcoholics and 30 matched control subjects with no family history of psychiatric or substance abuse problems. The control subjects were matched for demographic variables, drug use histories, and alcohol use histories. Each individual was tested on three occasions, receiving, in random order, placebo, 0.75 ml/kg of ethanol, and 1.1 ml/kg of ethanol. Controlling for baseline prolactin measures and hormonal changes after placebo, the authors found that the sons of alcoholics had significantly lower prolactin levels in response to the high-dose ethanol challenge.
作者评估了血清催乳素水平的变化，以此作为衡量30名健康的、有饮酒习惯的酗酒者成年儿子与30名无精神疾病或药物滥用家族史的匹配对照者对乙醇反应差异的指标。对照者在人口统计学变量、药物使用史和饮酒史方面进行了匹配。每个个体接受三次测试，按随机顺序分别给予安慰剂、0.75毫升/千克乙醇和1.1毫升/千克乙醇。在控制了基线催乳素测量值和安慰剂后的激素变化后，作者发现，在高剂量乙醇激发试验中，酗酒者的儿子的催乳素水平显著较低。
