从紧急和白血病性骨髓生成得出空间结论的良好生产规范（GMP）研究
GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis.
作者信息
Niederkorn Madeline, Starczynowski Daniel T
机构信息
Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
出版信息
Cell Stem Cell. 2017 May 4;20(5):579-581. doi: 10.1016/j.stem.2017.04.005.
Abstract
Hematopoietic stem cells (HSCs) in the bone marrow (BM) form mature blood cells of all lineages through expansion of lineage-biased progenitors. In a recent issue of Nature, Hérault et al. (2017) uncover a unique spatiotemporal mechanism of granulocyte-macrophage progenitors (GMPs) employed in emergency hematopoiesis that is also hijacked in leukemia.
摘要
骨髓中的造血干细胞（HSCs）通过谱系偏向祖细胞的扩增形成所有谱系的成熟血细胞。在最近一期的《自然》杂志上，埃罗等人（2017年）揭示了粒细胞-巨噬细胞祖细胞（GMPs）在应急造血中采用的一种独特的时空机制，而这种机制在白血病中也被利用。
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本文引用的文献
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Nature. 2017 Apr 6;544(7648):53-58. doi: 10.1038/nature21693. Epub 2017 Mar 29.
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Single-cell analysis of mixed-lineage states leading to a binary cell fate choice.导致二元细胞命运选择的混合谱系状态的单细胞分析。
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