Institute of Biostructure and Bioimaging, National Research Council (CNR), via P. Gaifami 18, 95126, Catania, Italy.
Department of Chemical Sciences, University of Catania, Viale A. Doria 6, 95125, Catania, Italy.
Eur J Med Chem. 2017 Jul 28;135:447-457. doi: 10.1016/j.ejmech.2017.04.060. Epub 2017 Apr 24.
Increasing evidence is accumulating, showing that neurodegenerative disorders are somehow associated with the toxicity of amyloid aggregates, metal ion dyshomeostasis as well as with products generated by oxidative stress. Within the biological oxidation products, acrolein does have a prominent role. A promising strategy to deal with the above neurogenerative disorders is to use multi-functions bio-molecules. Herein, we show how a class of bio-conjugates takes advantage of the antiaggregating, antioxidant and antiglycating properties of trehalose and carnosine. Their ability to sequester acrolein and to inhibit both self- and metal-induced aggregation is here reported. The copper(II) coordination properties of a new trehalose-carnosine conjugate and the relative antioxidant effects have also been investigated.
越来越多的证据表明，神经退行性疾病与淀粉样蛋白聚集的毒性、金属离子动态平衡以及氧化应激产生的产物在某种程度上有关。在生物氧化产物中，丙烯醛具有突出的作用。应对上述神经退行性疾病的一种有前途的策略是使用多功能生物分子。在此，我们展示了一类生物缀合物如何利用海藻糖和肌肽的抗聚集、抗氧化和抗糖化特性。本文报道了它们结合丙烯醛的能力，以及抑制自身和金属诱导聚集的能力。还研究了一种新的海藻糖-肌肽缀合物的铜（II）配位性质及其相对抗氧化作用。
