对三组不同剂量的奈多罗米钠通过压力定量气雾剂给药于运动诱发性支气管收缩哮喘患者的效果与安慰剂进行的对比研究。
A comparative study of the effect of three doses of nedocromil sodium and placebo given by pressurized aerosol to asthmatics with exercise-induced bronchoconstriction.
作者信息
Vilsvik J, Schaanning J
机构信息
Lung Department, Regional Hospital, University of Trondheim, Norway.
出版信息
Ann Allergy. 1988 Nov;61(5):367-70.
PMID:2847600
Abstract
The effect of placebo and 1 mg, 4 mg, or 8 mg nedocromil sodium, administered 60 minutes prior to treadmill challenge, was determined in a double-blind study of 12 adult asthmatics with reproducible exercise-induced bronchoconstriction. All nedocromil sodium treatments gave significantly smaller falls in PEFR than placebo. Four and 8 mg gave significantly greater protection than 1 mg.
摘要
在一项针对12名患有可重复性运动诱发性支气管收缩的成年哮喘患者的双盲研究中，确定了在跑步机激发试验前60分钟给予安慰剂以及1毫克、4毫克或8毫克奈多罗米钠的效果。与安慰剂相比，所有奈多罗米钠治疗组的呼气峰流速（PEFR）下降幅度均显著更小。4毫克和8毫克组的保护作用明显优于1毫克组。
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