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干燥综合征综合综述：分类标准、危险因素及信号通路

A comprehensive review of Sjögren's syndrome: Classification criteria, risk factors, and signaling pathways.

作者信息

Zhao Ting, Zhang Runrun, Li Zhaofu, Qin Dongdong, Wang Xinchang

机构信息

Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Neuropsychiatric Diseases, Yunnan University of Chinese Medicine, Kunming, 650500, China.

The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China.

出版信息

Heliyon. 2024 Aug 15;10(17):e36220. doi: 10.1016/j.heliyon.2024.e36220. eCollection 2024 Sep 15.

DOI:10.1016/j.heliyon.2024.e36220
PMID:39286095
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11403439/
Abstract

Sjögren's syndrome (SS) is a chronic autoimmune disease that affects the exocrine glands and may lead to a range of systemic symptoms that impact various organs. Both innate and adaptive immune pathways might trigger the disease. Studying the signaling pathways underlying SS is crucial for enhancing diagnostic and therapeutic effectiveness. SS poses an ongoing challenge for medical professionals owing to the limited therapeutic options available. This review offers a comprehensive understanding of the intricate nature of SS, encompassing disease classification criteria, risk factors, and signaling pathways in immunity and inflammation. The advancements summarized herein have the potential to spark new avenues of research into SS.

摘要

干燥综合征（SS）是一种慢性自身免疫性疾病，会影响外分泌腺，并可能导致一系列影响多个器官的全身症状。先天性和适应性免疫途径都可能引发该疾病。研究干燥综合征背后的信号通路对于提高诊断和治疗效果至关重要。由于可用的治疗选择有限，干燥综合征对医学专业人员来说仍然是一个持续的挑战。这篇综述全面介绍了干燥综合征的复杂本质，包括疾病分类标准、风险因素以及免疫和炎症中的信号通路。本文总结的进展有可能为干燥综合征的研究开辟新的途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/6763126b7181/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/c54c8513c7ad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/dd18aebd174b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/6763126b7181/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/c54c8513c7ad/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/dd18aebd174b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/19f5/11403439/6763126b7181/gr3.jpg

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本文引用的文献

1
Interactions between TNFAIP3, PTPN22, and TRAF1-C5 gene polymorphisms in patients with primary Sjögren's syndrome.原发性干燥综合征患者中TNFAIP3、PTPN22和TRAF1-C5基因多态性之间的相互作用
Arch Rheumatol. 2024 Feb 1;39(1):60-70. doi: 10.46497/ArchRheumatol.2024.10108. eCollection 2024 Mar.
2
Beyond sicca: high prevalence and predictors of baseline and worsening systemic involvement in patients with Sjögren's disease.除干燥症状外：干燥综合征患者基线及病情进展时全身受累的高患病率及预测因素
Rheumatol Adv Pract. 2024 Mar 6;8(2):rkae035. doi: 10.1093/rap/rkae035. eCollection 2024.
3
Implications of IFNγ SNP rs2069705 in primary Sjögren's syndrome: transcriptional activation and B cell infiltration.
IFNγ SNP rs2069705 在原发性干燥综合征中的意义：转录激活和 B 细胞浸润。
Am J Physiol Cell Physiol. 2024 May 1;326(5):C1494-C1504. doi: 10.1152/ajpcell.00661.2023. Epub 2024 Feb 26.
4
Human umbilical cord mesenchymal stem cells improve disease characterization of Sjogren's syndrome in NOD mice through regulation of gut microbiota and Treg/Th17 cellular immunity.人脐带间充质干细胞通过调节肠道微生物群和 Treg/Th17 细胞免疫改善 NOD 小鼠干燥综合征的疾病特征。
Immun Inflamm Dis. 2024 Jan;12(1):e1139. doi: 10.1002/iid3.1139.
5
Impact of sex differences on the clinical presentation, pathogenesis, treatment and prognosis of Sjögren's syndrome.性别差异对干燥综合征临床表现、发病机制、治疗及预后的影响。
Immunology. 2024 Apr;171(4):513-524. doi: 10.1111/imm.13740. Epub 2023 Dec 29.
6
Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta-analysis.TNFSF13B 多态性与原发性干燥综合征患者原发性干燥综合征易感性的相关性：荟萃分析。
Immun Inflamm Dis. 2023 Dec;11(12):e1103. doi: 10.1002/iid3.1103.
7
Characterisation of macrophage infiltration and polarisation based on integrated transcriptomic and histological analyses in Primary Sjögren's syndrome.原发性干燥综合征中基于整合转录组学和组织学分析的巨噬细胞浸润和极化特征。
Front Immunol. 2023 Nov 3;14:1292146. doi: 10.3389/fimmu.2023.1292146. eCollection 2023.
8
Identification of immunological characteristics and cuproptosis-related molecular clusters in primary Sjögren's syndrome.原发性干燥综合征中免疫特征和铜死亡相关分子簇的鉴定。
Int Immunopharmacol. 2024 Jan 5;126:111251. doi: 10.1016/j.intimp.2023.111251. Epub 2023 Nov 18.
9
Risk of subclinical atherosclerosis in primary Sjogren's syndrome: A systematic review and meta-analysis.原发性干燥综合征患者亚临床动脉粥样硬化风险：系统评价和荟萃分析。
Eur J Intern Med. 2024 Apr;122:93-101. doi: 10.1016/j.ejim.2023.11.007. Epub 2023 Nov 15.
10
Neurological Involvement in Patients with Primary Sjögren's Syndrome: A Retrospective Cross-Sectional Study.原发性干燥综合征患者的神经受累情况：一项回顾性横断面研究。
Ann Indian Acad Neurol. 2023 Jul-Aug;26(4):424-430. doi: 10.4103/aian.aian_138_23. Epub 2023 Aug 8.