Irabor David O, Oluwasola Olayiwola A, Ogunbiyi Olufemi J, Ogun Olabiyi G, Okolo Clement A, Melas Marilena, Gruber Stephen B, Shi Chanjuan, Raskin Leon
Department of Surgery, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Department of Pathology, College of Medicine, University of Ibadan, Ibadan, Nigeria.
Anticancer Res. 2017 May;37(5):2649-2654. doi: 10.21873/anticanres.11612.
Colorectal cancer (CRC) is the fifth most common cancer in Africa, with significant differences in incidence, biology and clinical behavior from other populations.
We studied prevalence and clinicopathological features of microsatellite instability (MSI) and young onset CRC in 83 archival samples from the University of Ibadan, Nigeria.
Nigerian cases of CRC were MSI-high in 43% and MSI-high CRC had significantly lower histological heterogeneity than microsatellite-stable CRC (20% vs. 55% respectively, p=0.046). Presence of signet ring cell differentiation (10-50% of tumor) was significantly higher in younger patients with CRC (<50 years) (odds ratio(OR)=5.93, 95% confidence interval(CI)=1.17-29.95, p=0.038). Poor differentiation (34%), invasive growth (96%), and high prevalence of mucinous (10%) and signet ring cell adenocarcinomas (4%) were among distinct features of Nigerian patients with CRC.
MSI-high CRC is more common in West Africa and more detailed molecular and genetic analysis is warranted as CRC incidence and mortality continue to increase in the Sub-Saharan Africa.
结直肠癌（CRC）是非洲第五大常见癌症，其发病率、生物学特性和临床行为与其他人群存在显著差异。
我们研究了来自尼日利亚伊巴丹大学的83份存档样本中微卫星不稳定性（MSI）和青年发病CRC的患病率及临床病理特征。
尼日利亚CRC病例中43%为微卫星高度不稳定（MSI-H），且MSI-H CRC的组织学异质性显著低于微卫星稳定CRC（分别为20%和55%，p = 0.046）。CRC年轻患者（<50岁）中印戒细胞分化（占肿瘤的10%-50%）的比例显著更高（优势比[OR]=5.93，95%置信区间[CI]=1.17-29.95，p = 0.038）。低分化（34%）、浸润性生长（96%）以及黏液腺癌（10%）和印戒细胞腺癌（4%）的高患病率是尼日利亚CRC患者的显著特征。
MSI-H CRC在西非更为常见，随着撒哈拉以南非洲地区CRC发病率和死亡率持续上升，有必要进行更详细的分子和基因分析。
