散发性结直肠癌中的微卫星不稳定性和生活方式因素。
Microsatellite Instability and Life Style Factors in Sporadic Colorectal Cancer.
机构信息
Biostatistics and Cancer Epidemiology department, National Cancer Institute (NCI), Cairo University, Egypt.
Pathology Department, NCI, Cairo University, Egypt.
出版信息
Asian Pac J Cancer Prev. 2020 May 1;21(5):1471-1480. doi: 10.31557/APJCP.2020.21.5.1471.
BACKGROUND
Colorectal cancer (CRC) in Egypt is a relatively high young onset disease. As a form of heterogeneous cancer, there is interplay between genetic and environmental factors. We aimed at probing the association of life style factors and Microsatellite Instability (MSI) status that could provide more insights on carcinogenic process of CRC.
METHODS
One hundred incident sporadic CRC patients were involved. Information on risk factors of CRC was obtained and microsatellite instability status was predicted through evaluation of MMR protein expression via immunohistochemistry (IHC).
RESULTS
Median age was 47.50 years, females represented 54.0% and 36% of patients were Microsatellite Instability High (MSI-H). Most patients with right sided colon cancer (78.3%) were MSI-H while mostly stable or low MSS/MSI-L for left-sided colon and rectum (78.6%, 74.3% respectively, p<0.001). Patients with low physical activity had higher risk of MSS/MSI-L than those with moderate or high activity p =0.026. Patients with BMI greater than 30 Kg/m2 had higher MSS/MSI-L (75.5%) than those with BMI between 25-30 Kg/m2 (60.6%) and those with normal BMI.
背景
埃及的结直肠癌（CRC）是一种相对高发的年轻发病疾病。作为一种异质性癌症，遗传和环境因素之间存在相互作用。我们旨在探讨生活方式因素与微卫星不稳定性（MSI）状态的相关性，这可以为 CRC 的致癌过程提供更多的见解。
方法
纳入了 100 例偶发性 CRC 患者。通过评估免疫组织化学（IHC）中 MMR 蛋白表达来获得 CRC 危险因素的信息，并预测微卫星不稳定性状态。
结果
中位年龄为 47.50 岁，女性占 54.0%，36%的患者为微卫星不稳定高（MSI-H）。大多数右侧结肠癌（78.3%）患者为 MSI-H，而左侧结肠和直肠的稳定或低 MSS/MSI-L 居多（分别为 78.6%、74.3%，p<0.001）。体力活动较少的患者发生 MSS/MSI-L 的风险高于体力活动中等或较高的患者，p=0.026。BMI 大于 30 Kg/m2 的患者发生 MSS/MSI-L 的比例（75.5%）高于 BMI 在 25-30 Kg/m2 之间的患者（60.6%）和 BMI 正常的患者。
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