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硫酸脱氢表雄酮对心血管疾病患者的预后价值：一项系统评价和荟萃分析。

Prognostic Value of Dehydroepiandrosterone Sulfate for Patients With Cardiovascular Disease: A Systematic Review and Meta-Analysis.

作者信息

Wu Ting-Ting, Chen Yuan, Zhou Yun, Adi Dilare, Zheng Ying-Ying, Liu Fen, Ma Yi-Tong, Xie Xiang

机构信息

Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi, China.

出版信息

J Am Heart Assoc. 2017 May 5;6(5):e004896. doi: 10.1161/JAHA.116.004896.

DOI:10.1161/JAHA.116.004896
PMID:28476876
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5524067/
Abstract

BACKGROUND

The aim of the present study was to estimate the impact of dehydroepiandrosterone sulfate (DHEAS) on the prognosis of patients with cardiovascular disease by performing a systematic review and meta-analysis.

METHODS AND RESULTS

The Embase, PubMed, Web of Science, CNKI, and WanFang databases were searched up to September 5, 2016, to identify eligible studies. The quality of each study was assessed using the Newcastle-Ottawa Scale. The association between DHEAS, either on admission or at discharge, and cardiovascular disease outcomes were reviewed. The overall risk ratio for the effect of DHEAS on all-cause mortality and fatal and nonfatal cardiovascular events was pooled using a fixed-effects or a random-effects model. The publication bias was evaluated using funnel plots. Twenty-five studies were included for systematic review. The follow-up duration ranged from 1 to 19 years. Eighteen studies were included in the meta-analysis. We found that lower DHEAS levels indicated a significant increased risk for all-cause mortality (risk ratio, 1.47; 95% CI, 1.38-1.56 [<0.00001]), fatal cardiovascular event (risk ratio, 1.58; 95% CI, 1.30-1.91 [<0.00001]), and nonfatal cardiovascular event (risk ratio, 1.42; 95% CI, 1.24-1.62 [<0.0001]) in patients with cardiovascular disease.

CONCLUSIONS

Patients with cardiovascular disease who have lower DHEAS levels may have poorer prognosis than those with higher DHEAS levels.

摘要

背景

本研究旨在通过系统评价和荟萃分析评估硫酸脱氢表雄酮（DHEAS）对心血管疾病患者预后的影响。

方法与结果

检索了截至2016年9月5日的Embase、PubMed、Web of Science、中国知网和万方数据库，以确定符合条件的研究。使用纽卡斯尔-渥太华量表评估每项研究的质量。回顾了入院时或出院时DHEAS与心血管疾病结局之间的关联。使用固定效应模型或随机效应模型汇总DHEAS对全因死亡率以及致命和非致命心血管事件影响的总体风险比。使用漏斗图评估发表偏倚。纳入25项研究进行系统评价。随访时间为1至19年。18项研究纳入荟萃分析。我们发现，心血管疾病患者中较低的DHEAS水平表明全因死亡率（风险比，1.47；95%可信区间，1.38 - 1.56[<0.00001]）、致命心血管事件（风险比，1.58；95%可信区间，1.30 - 1.91[<0.00001]）和非致命心血管事件（风险比，1.42；95%可信区间，1.24 - 1.62[<0.0001]）的风险显著增加。

结论

DHEAS水平较低的心血管疾病患者可能比DHEAS水平较高的患者预后更差。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/50659bbacb6b/JAH3-6-e004896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/e27538571fee/JAH3-6-e004896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/bb271d4bc817/JAH3-6-e004896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/5af52fb9ce67/JAH3-6-e004896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/5aed455ff96a/JAH3-6-e004896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/6d62ce60fd47/JAH3-6-e004896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/50659bbacb6b/JAH3-6-e004896-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/e27538571fee/JAH3-6-e004896-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/bb271d4bc817/JAH3-6-e004896-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/5af52fb9ce67/JAH3-6-e004896-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/5aed455ff96a/JAH3-6-e004896-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/6d62ce60fd47/JAH3-6-e004896-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26b9/5524067/50659bbacb6b/JAH3-6-e004896-g006.jpg

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