Tiwari Nikita, Pandit Raksha, Gaikwad Swapnil, Gade Aniket, Rai Mahendra
Department of Biotechnology, SGB Amravati University, Amravati 444 602, Maharashtra, India.
Department of Biotechnology, Engineering School of Lorena, University of Sao Paulo, Estrada Municipal do, Campinho, sn, 12602-810 Lorena, SP, Brazil.
IET Nanobiotechnol. 2017 Mar;11(2):205-211. doi: 10.1049/iet-nbt.2016.0003.
The authors report the biological synthesis of zinc oxide nanoparticles (ZnO-NPs) from the petals extract of L. (rose). Its efficacy was evaluated against two dermatophytes: namely: and which cause onychomycosis. The activity of antibiotics against the tested dermatophytes was enhanced, when evaluated in combination with ZnO-NPs. The synthesised ZnO-NPs were preliminary detected by using ultraviolet UV visible spectroscopy, which showed specific absorbance. The ZnO-NPs were further characterised by nanoparticle tracking analysis (NTA), Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), X-ray diffraction and Zetasizer. Moreover, nanoparticles containing nail paint (nanopaint) was formulated and its antifungal activity was also assessed against and . ZnO-NPs and formulated nanopaint containing ZnO-NPs, both showed significant antifungal activity. The maximum activity was noted against and lesser against Minimum inhibitory concentration of ZnO-NPs was also determined against the dermatophytes causing onychomycosis infection. ZnO-NPs can be utilised as a potential antifungal agent for the treatment of onychomycosis after more experimental trials.
作者报道了从玫瑰花瓣提取物中生物合成氧化锌纳米颗粒（ZnO-NPs）。评估了其对两种引起甲癣的皮肤癣菌的功效，即[此处原文两种皮肤癣菌名称缺失]。当与ZnO-NPs联合评估时，抗生素对受试皮肤癣菌的活性增强。通过紫外可见光谱对合成的ZnO-NPs进行了初步检测，结果显示有特定吸光度。通过纳米颗粒跟踪分析（NTA）、傅里叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、X射线衍射和Zetasizer对ZnO-NPs进行了进一步表征。此外，还配制了含纳米颗粒的指甲油（纳米指甲油），并评估了其对[此处原文两种皮肤癣菌名称缺失]的抗真菌活性。ZnO-NPs和配制的含ZnO-NPs的纳米指甲油均显示出显著的抗真菌活性。对[此处原文两种皮肤癣菌名称缺失]的活性最高，对[此处原文两种皮肤癣菌名称缺失]的活性较低。还测定了ZnO-NPs对引起甲癣感染的皮肤癣菌的最低抑菌浓度。经过更多实验试验后，ZnO-NPs可作为治疗甲癣的潜在抗真菌剂。
