Roy Dijendra Nath, Goswami Ritobrata
Department of Bioengineering, National Institute of Technology, NIT-Agartala, Jirania, 799046, Tripura, India.
School of Bio Science, Sir JC Bose Laboratory Complex, Indian Institute of Technology, Kharagpur, 721302, West Bengal, India.
Methods Mol Biol. 2017;1585:37-50. doi: 10.1007/978-1-4939-6877-0_3.
Since the discovery of IL-9 almost three decades back as a growth factor, we have come a long way to understand its pleiotropic functions in the immune system. Despite its many functions, IL-9 still remains as an understudied cytokine. In the last decade, renewed emphasis has been provided to understand the biology of IL-9. Any growth factor or cytokine signals via its cognate receptor to mediate biological functions. In this chapter, we discuss the IL-9 signal transduction in different cell types, which would then exert its distinct functions.
自从近三十年前白细胞介素-9作为一种生长因子被发现以来，我们在理解其在免疫系统中的多效性功能方面已经取得了长足的进展。尽管白细胞介素-9具有多种功能，但它仍然是一种研究较少的细胞因子。在过去十年中，人们重新重视对白细胞介素-9生物学特性的理解。任何生长因子或细胞因子都通过其同源受体发出信号来介导生物学功能。在本章中，我们将讨论白细胞介素-9在不同细胞类型中的信号转导，随后它会发挥其独特的功能。
