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可调节胃束带失败后进行减重手术翻修的结局的系统评价和荟萃分析

Systematic Review and Meta-Analysis of Outcomes After Revisional Bariatric Surgery Following a Failed Adjustable Gastric Band.

作者信息

Sharples Alistair J, Charalampakis Vasileios, Daskalakis Markos, Tahrani Abd A, Singhal Rishi

机构信息

Department of Upper GI Surgery, Heart of England NHS Foundation Trust, Birmingham, UK.

Department of Diabetes and Endocrinology, Heart of England NHS Foundation Trust, Birmingham, UK.

出版信息

Obes Surg. 2017 Oct;27(10):2522-2536. doi: 10.1007/s11695-017-2677-7.

Abstract

INTRODUCTION

Laparoscopic adjustable gastric band (LAGB)-related complications have been reported in significant numbers of patients often leading to band removal. Increasingly revisional bariatric surgery (RBS) is offered, most commonly either band to Roux-en-Y gastric bypass (B-RYGB) or band to sleeve gastrectomy (B-SG).

OBJECTIVES

We conducted a systematic review and meta-analysis of studies to evaluate the efficacy of RBS following failed LAGB.

METHODS

Medline, Embase, The Cochrane Library and NHS Evidence were searched for English language studies assessing patients who had undergone LAGB and who subsequently underwent either B-RYGB or B-SG.

RESULTS

Thirty-six studies met the inclusion criteria. There were 2617 patients. B-RYGB was performed in 60.5% (n = 1583). There was one death within 30 days (0.0004%). The overall pooled morbidity rate was 13.2%. There was no difference between the B-RYGB and B-SG groups in morbidity, leak rate or return to theatre. Percentage excess weight loss (%EWL) following the revisional procedure for all patients combined at 6, 12 and 24 months was 44.5, 55.7 and 59.7%, respectively. There was no statistical difference in %EWL between B-RYGB and B-SG at any time point. The rates of remission of diabetes, hypertension and obstructive sleep apnoea were 46.5, 35.9 and 80.8%, respectively.

CONCLUSIONS

Randomised controlled trials (RCTs) do not exist on this issue but the available observational evidence does suggest that RBS is associated with generally good outcomes similar to those experienced after primary surgery. Further, high-quality research, particularly RCTs, is required to assess long-term weight loss, comorbidity and quality of life outcomes.

摘要

引言

大量接受腹腔镜可调节胃束带术(LAGB)的患者出现了相关并发症,常导致胃束带移除。越来越多的患者接受了减重手术翻修术(RBS),最常见的是从胃束带术转换为 Roux-en-Y 胃旁路术(B-RYGB)或从胃束带术转换为袖状胃切除术(B-SG)。

目的

我们对相关研究进行了系统评价和荟萃分析,以评估 LAGB 失败后 RBS 的疗效。

方法

检索了 Medline、Embase、Cochrane 图书馆和英国国家医疗服务体系证据平台,查找评估接受过 LAGB 且随后接受了 B-RYGB 或 B-SG 的患者的英文研究。

结果

36 项研究符合纳入标准。共有 2617 例患者。60.5%(n = 1583)的患者接受了 B-RYGB。30 天内有 1 例死亡(0.0004%)。总体合并发病率为 13.2%。B-RYGB 组和 B-SG 组在发病率、渗漏率或再次手术率方面无差异。所有患者在翻修手术后 6、12 和 24 个月的超重体重减轻百分比(%EWL)分别为 44.5%、55.7%和 59.7%。在任何时间点,B-RYGB 和 B-SG 之间的 %EWL 均无统计学差异。糖尿病、高血压和阻塞性睡眠呼吸暂停的缓解率分别为 46.5%、35.9%和 80.8%。

结论

关于这个问题不存在随机对照试验(RCT),但现有观察性证据确实表明,RBS 的总体结果良好,与初次手术后的情况相似。此外,需要高质量的研究,尤其是 RCT,来评估长期体重减轻、合并症和生活质量结果。

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