Rodsaward Pongsawat, Prueksrisakul Titipong, Deekajorndech Tawatchai, Edwards Steven W, Beresford Michael W, Chiewchengchol Direkrit
Center of Excellence in Immunology and Immune-mediated Disease, Faculty of Medicine, Chulalongkorn University, Rama 4 Road, Pathumwan, Bangkok, 10330, Thailand.
Department of Oral Medicine, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Am J Clin Dermatol. 2017 Dec;18(6):755-762. doi: 10.1007/s40257-017-0286-9.
Oral ulcers are the most common mucosal sign in juvenile-onset systemic lupus erythematosus (JSLE). The ulcers are one of the key clinical features; however, the terminology of oral ulcers, especially in JSLE patients, is often vague and ill-defined. In fact, there are several clinical manifestations of oral ulcers in JSLE, and some lesions occur when the disease is active, indicating that early management of the disease should be started. Oral ulcers are classified as lupus erythematosus (LE) specific, where the lesional biopsy shows a unique pattern of mucosal change in LE, and LE nonspecific, where the ulcers and their histopathological findings can be found in other oral diseases. Here, the clinical manifestations, diagnosis and management of oral ulcers in JSLE patients are reviewed.
口腔溃疡是青少年型系统性红斑狼疮（JSLE）最常见的黏膜表现。这些溃疡是关键的临床特征之一；然而，口腔溃疡的术语，尤其是在JSLE患者中，往往模糊且定义不明确。事实上，JSLE患者的口腔溃疡有多种临床表现，并且有些病变在疾病活动时出现，这表明应尽早开始对该疾病进行管理。口腔溃疡分为狼疮特异性（LE），即病变活检显示LE中独特的黏膜变化模式，以及LE非特异性，即溃疡及其组织病理学表现也可见于其他口腔疾病。在此，对JSLE患者口腔溃疡的临床表现、诊断及管理进行综述。
