以非典型多形红斑样皮损为表现的系统性红斑狼疮：一项诊断挑战。
Systemic lupus erythematosus presenting as atypical erythema multiforme-like lesions: a diagnostic challenge.
作者信息
Hu Xiaojing, Liu Fen, Zong Juanjuan
机构信息
The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, 49 Fuzhou Road, Nanchang, 330006, China.
Jiangxi Provincial Key Laboratory of Oral Diseases, Nanchang, China.
出版信息
BMC Oral Health. 2025 Mar 8;25(1):361. doi: 10.1186/s12903-025-05743-7.
OBJECTIVES
Systemic Lupus Erythematosus (SLE) can cause oral mucosal lesions, it is a severe autoimmune disease, manifesting as variable kinds of oral lesions. Occasionally, these clinical manifestations maybe be misdiagnosed as other diseases. The aim of the present article is to report a rare case of SLE oral mucosa lesions masquerading as an Erythema multiforme (EM) oral lesions in a young man.
CASE PRESENTATION
A 34-year-old man with acutely oral lesions for about 10 days, presenting as diffusely oral mucosal hyperemia, erosions and ulcerations. The history, the clinical manifestations of the oral mucosal lesions, palms erythematous plaques and painless target lesions, lower limbs painless erythema and laboratory tests results were comprehensively considered. Finally the case was diagnosed as SLE.
CONCLUSIONS
The report of EM-like oral mucosal lesion of SLE is an extremely rare finding. In the diagnosis of SLE or EM, it is important to consider the history, clinical information and hematological examination. Sometimes histopathology and immunofluorescence are necessary.
目的
系统性红斑狼疮（SLE）可导致口腔黏膜病变，它是一种严重的自身免疫性疾病，表现为多种口腔病变。这些临床表现偶尔可能被误诊为其他疾病。本文旨在报告一例罕见的SLE口腔黏膜病变伪装成多形红斑（EM）口腔病变的青年男性病例。
病例介绍
一名34岁男性，口腔急性病变约10天，表现为口腔黏膜弥漫性充血、糜烂和溃疡。综合考虑病史、口腔黏膜病变的临床表现、手掌红斑性斑块和无痛靶形损害、下肢无痛性红斑以及实验室检查结果。最终该病例被诊断为SLE。
结论
SLE类似EM的口腔黏膜病变报告极为罕见。在诊断SLE或EM时，考虑病史、临床信息和血液学检查很重要。有时组织病理学和免疫荧光检查是必要的。
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