富含马钱素的（Artocarpus altilis）心材提取物可预防 UVB 诱导的真皮成纤维细胞机械损伤。
Artocarpin-enriched (Artocarpus altilis) Heartwood Extract Provides Protection Against UVB-induced Mechanical Damage in Dermal Fibroblasts.
机构信息
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences and Center of Excellence for Innovation in Chemistry, Naresuan University, Phitsanulok, Thailand.
Engineering and Cutaneous Biology Laboratory, UMR 1098, University of Bourgogne Franche-Comte, Besançon, France.
出版信息
Photochem Photobiol. 2017 Oct;93(5):1232-1239. doi: 10.1111/php.12788. Epub 2017 Jul 25.
This study aimed to evaluate the protective effect of artocarpin-enriched (Artocarpus altilis) heartwood extract on the mechanical properties of UVB-irradiated fibroblasts. Human skin fibroblasts were pretreated with 50 μg/mL extract and later irradiated with UVB (200 mJ/cm ). They were then cultured within three-dimensional of free-floating and tense collagen lattices. The pretreatment of fibroblasts with the extract prior to UVB radiation showed cells protection against UVB-induced suppression of α-SMA expression, fibroblast migration and contraction. These results reveal that the extract prevents mechanical damages induced by UVB irradiation in fibroblast-embedded collagen lattices, and therefore, has a potential as a natural photo-protectant.
本研究旨在评估富含鸡矢藤素（Artocarpus altilis）的心材提取物对 UVB 照射的成纤维细胞机械性能的保护作用。将人皮肤成纤维细胞用 50μg/mL 的提取物预处理，然后用 UVB（200mJ/cm）照射。然后，它们在三维自由漂浮和紧张胶原格子中培养。在 UVB 辐射之前用提取物预处理成纤维细胞显示出对 UVB 诱导的 α-SMA 表达、成纤维细胞迁移和收缩的抑制的细胞保护作用。这些结果表明，该提取物可防止 UVB 照射在成纤维细胞嵌入胶原格子中引起的机械损伤，因此具有作为天然光保护剂的潜力。
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