9,10-菲醌与镉对气道上皮细胞促炎反应的协同作用。
Synergic effects of 9,10-phenanthrenequinone and cadmium on pro-inflammatory responses in airway epithelial cells.
作者信息
Honda Akiko, Chowdhury Pratiti Home, Ito Sho, Okano Hitoshi, Onishi Toshinori, Kawaryu Yusuke, Ueda Kayo, Takano Hirohisa
机构信息
Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan.
出版信息
Environ Toxicol Pharmacol. 2017 Jun;52:276-279. doi: 10.1016/j.etap.2017.04.019. Epub 2017 Apr 26.
We investigated the synergic effects of components of particulate matter with aerodynamic diameters ≤2.5μm (PM2.5) on airway inflammation. Co-exposure to cadmium (Cd) and 9,10-phenanthrenequinone (9,10-PQ) additively/synergistically increased pro-inflammatory responses in airway epithelial cells, whereas co-exposure to Cd and phenanthrene resulted in no acceleration. These results suggest that the combination of metal and a quinone derivative can contribute to the exacerbation of respiratory diseases by PM2.5.
我们研究了空气动力学直径≤2.5μm的颗粒物（PM2.5）各组分对气道炎症的协同作用。镉（Cd）与9,10 - 菲醌（9,10 - PQ）共同暴露会累加/协同增加气道上皮细胞中的促炎反应，而Cd与菲共同暴露则不会加速这种反应。这些结果表明，金属与醌衍生物的组合可能会导致PM2.5加剧呼吸系统疾病。
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