Laboratory of Psychophysics, Brain Mind Institute, École Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
Faculté des Sciences Sociales et Politiques, Institut de Psychologie, Bâtiment Geopolis, Lausanne, Switzerland.
Psychiatry Res. 2017 Aug;254:251-257. doi: 10.1016/j.psychres.2017.04.051. Epub 2017 Apr 26.
Visual backward masking is strongly deteriorated in patients with schizophrenia. Masking deficits are associated with strongly reduced amplitudes of the global field power in the EEG. Healthy participants who scored high in cognitive disorganization (a schizotypic trait) were impaired in backward masking compared to participants who scored low. Here, we show that the global field power is also reduced in healthy participants scoring high (n=25) as compared to low (n=20) in cognitive disorganization, though quantitatively less pronounced than in patients (n=10). These results point to similar mechanisms underlying visual backward masking deficits along the schizophrenia spectrum.
视觉后向掩蔽在精神分裂症患者中严重受损。掩蔽缺陷与 EEG 中的全局场功率幅度明显降低有关。在认知组织障碍（一种类精神特质）方面得分较高的健康参与者与得分较低的参与者相比，在后向掩蔽中受到损害。在这里，我们表明，在认知组织障碍方面得分较高（n=25）的健康参与者的全局场功率也降低（n=20），尽管与患者（n=10）相比，数量上的降低不太明显。这些结果表明，在精神分裂症谱系中，视觉后向掩蔽缺陷存在类似的机制。
