淋巴瘤和白血病的肺部表现

Pulmonary Manifestations of Lymphoma and Leukemia.

作者信息

Bashoura Lara, Eapen George A, Faiz Saadia A

机构信息

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, 1400 Pressler Unit 1462, Houston, TX 77030-1402, USA.

出版信息

Clin Chest Med. 2017 Jun;38(2):187-200. doi: 10.1016/j.ccm.2016.12.003.

DOI:10.1016/j.ccm.2016.12.003

PMID:28477632

Abstract

Pulmonary manifestations of lymphoma and leukemia may involve multiple structures within the thoracic cavity. Malignant lymphoma typically originates in lymph nodes, but concomitant or primary presentations with parenchymal, pleural, or tracheobronchial disease may occur. Once infection is excluded, leukemic infiltrates may be related to malignancy, hemorrhage, or secondary pulmonary alveolar proteinosis. Confirmation with cytology or flow cytometry is recommended to diagnose malignant pleural effusions in hematologic malignancies. In chronic leukemia with progressive pulmonary findings, exclusion of a synchronous malignancy or Richter syndrome should be performed. Venous thromboembolism may present in patients with leukemia and lymphoma despite the presence of thrombocytopenia.

摘要

淋巴瘤和白血病的肺部表现可能累及胸腔内的多个结构。恶性淋巴瘤通常起源于淋巴结，但也可能伴有实质、胸膜或气管支气管疾病的并发或原发表现。一旦排除感染，白血病浸润可能与恶性肿瘤、出血或继发性肺泡蛋白沉积症有关。建议通过细胞学或流式细胞术确诊血液系统恶性肿瘤中的恶性胸腔积液。对于有进行性肺部表现的慢性白血病患者，应排除同步性恶性肿瘤或里氏综合征。白血病和淋巴瘤患者即使存在血小板减少也可能出现静脉血栓栓塞。