Lessard Isabelle, Lavoie Caroline, Côté Isabelle, Mathieu Jean, Brais Bernard, Gagnon Cynthia
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean, Québec, Canada; Centre de recherche Charles-Le-Moyne, Faculty of Medicine and Health Sciences, Université de Sherbrooke, Québec, Canada.
Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre intégré universitaire de santé et de services sociaux du Saguenay-Lac-St-Jean, Québec, Canada.
J Neurol Sci. 2017 Jun 15;377:193-196. doi: 10.1016/j.jns.2017.03.046. Epub 2017 Mar 29.
Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) is a neuromuscular disease leading to several impairments, including decrease of lower limb coordination. The Lower Extremity Motor Coordination Test (LEMOCOT) is an outcome measure recently developed for stroke population. The aim of this study was to document: 1) intra- and interrater reliability; 2) the standard error of measurement and minimal detectable change; and 3) the construct validity of the measurements obtained with the LEMOCOT in the adult ARSACS population.
The LEMOCOT has shown a good intra- and interrater reliability with an intraclass correlation coefficient ranging from 0.92 to 0.97 for both dominant and non-dominant side. The construct validity (hypothesis testing) is satisfying where LEMOCOT's score negatively correlated with participants' age (r=-0.74) and the score of the Scale for the Assessment and Rating of Ataxia (r=-0.86) and positively correlated with the balance and mobility tests (r=0.82 with the Berg Balance Scale, r=0.61 with the Six-Minute Walk Test, r=0.57 with the 10-Meter Walk Test). The LEMOCOT was also able to distinguish between patients according to disease stages.
The LEMOCOT is a valid and reliable tool to assess lower limb coordination in the ARSACS population for whom the lack of coordination is a common symptom.
夏尔沃 - 萨格奈常染色体隐性痉挛性共济失调（ARSACS）是一种神经肌肉疾病，会导致多种功能障碍，包括下肢协调性下降。下肢运动协调测试（LEMOCOT）是最近为中风人群开发的一种结局指标。本研究的目的是记录：1）评分者内和评分者间的可靠性；2）测量的标准误差和最小可检测变化；3）在成年ARSACS人群中使用LEMOCOT获得的测量结果的结构效度。
LEMOCOT在评分者内和评分者间均显示出良好的可靠性，优势侧和非优势侧的组内相关系数范围为0.92至0.97。结构效度（假设检验）令人满意，LEMOCOT的得分与参与者的年龄呈负相关（r = -0.74），与共济失调评估和评分量表的得分呈负相关（r = -0.86），与平衡和运动测试呈正相关（与伯格平衡量表r = 0.82，与六分钟步行测试r = 0.61，与十米步行测试r = 0.57）。LEMOCOT还能够根据疾病阶段区分患者。
对于缺乏协调性是常见症状的ARSACS人群，LEMOCOT是评估下肢协调性的有效且可靠的工具。
